Opium

It is highly addictive substace. Withdrawal from opium causes nausea, tearing, yawning, chills, and sweating.

About 100 years age, opium had been used as a folk medicine, taken with a beverage or swallowed as a solid. It was smoked first time in China in 17th century.
Opium then made its way to Europe and North America, where it takes its place as a painkiller.

Tolerance (the need for higher and higher doses to maintain the same effect) and physical and psychological dependence develop quickly.